For instance, oliceridine acts as a G-protein-biased agonist for the μ-opioid receptor (μOR).44 By selectively activating the Gi signaling pathway, oliceridine aims to provide effective pain relief while reducing common side effects, such as respiratory depression and constipation, that are often associated with β-arrestin pathway activation. Here, GNAI1 is linked to Respiratory insufficiency due to muscle weakness.