Previous studies have research has shown that the transcription factor JUNB directly binds to the CD44 promoter sequence and regulates hematopoietic progenitor cell differentiation in vitro.[29] Here, JUNB motifs were found to be highly activated in the rCSC‐M subset (Figure 2H), and the Spearman correlation of TCGA BLCA cohort indicated a positive correlation between the expression of JUNB and CD44 (Figure 4G). The gene discussed is JUNB; the disease is bladder transitional cell carcinoma.