CCN2 and neoplasm: ECM remodeling is a critical process for the formation of fibrous tissue growth zones.[67] In addition, the ICAM1+ iCAFs subset exhibits a high level of CTGF expression, which plays a critical role in promoting tumor fibrosis and collagen deposition.[68] This process leads to the formation of immune‐exclusion physical barriers that prevent the infiltration of chemotherapeutic drugs and T cells.