The abundance of CXCL13+ CD4+ T cells, the tumor antigen‐specific T cells to immune‐checkpoint blockade,[44, 45] was significantly higher in primary tumors, and a subset of CD4+ T cells had high expression levels of several cytotoxic genes, including GZMB and GZMK (Figure 7H,I). This evidence concerns the gene CXCL13 and neoplasm.