C5AR2 and urinary bladder neoplasm: Additionally, under the control of the NF‐κB signaling pathway, CD10+ GPR77+ CAFs secrete IL‐6 and IL‐8, thereby maintaining the CSC phenotype through a paracrine mechanism.[57] Our study revealed the existence of two CSC subtypes in recurrent bladder tumors, indicating significant heterogeneity among these tumors.