The intricate interplay between tumor cells, stromal cells, and the ECM within the TME is closely associated with tumor immune evasion, metastasis, and recurrence.[54, 55] In this study, we aimed to investigate the specific ICAM1+ iCAFs subset in recurrent tumors and its signaling communication with CSCs and myeloid cells by constructing a cellcell interaction network through ligand‐receptor binding. Here, ICAM1 is linked to neoplasm.