Furthermore, Ueland et al. have highlighted that DKK1 might serve as a new mediator for platelet-mediated endothelial cell activation and play a critical role in the pathological process of atherosclerosis by mediating the inhibition of the Wnt/beta-catenin signaling pathway and the activation of the NF-kB pathway [13]. The gene discussed is CTNNB1; the disease is atherosclerosis.