Methods: A 1:1:1 case-control study was conducted and serum fasting blood glucose, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, SIRT1, IL-6, Aβ1-42, T-tau and P-tau-181 levels were evaluated in blood samples of 26 patients form the Alzheimer’s Disease group, 26 patients form the mild cognitive impairment group, and 26 individuals form the normal control group. Here, IL6 is linked to early-onset autosomal dominant Alzheimer disease.