,27 To determine whether ALKBH5-mediated regulation of energy metabolism is required for leukemogenesis in addition to reduction of TACC3 and AXL1 to limit AML survival, we generated Mll-AF9 mutant leukemia from Cre-rtTA-Alkbh5fl/fl mice.52 Here, KMT2A is linked to acute myeloid leukemia.