,31 We here use a hematopoiesis-specific Alkbh5-deficient murine system and model loss of ALKBH5 in Mll-AF9-driven leukemia to show that ALKBH5 regulates the hematopoietic stem and progenitor cell metabolic switch from glycolysis to oxidative phosphorylation (OXPHOS) via control of stability of metabolic gene transcripts, in particular of the TCA rate-limiting enzyme Ogdh. This evidence concerns the gene ALKBH5 and leukemia.