Research has shown that attenuation of TGF-β1, UUO and I/R treatment-induced renal fibrosis through MBD2 silencing or PT-MBD2-KO is due to MBD2 directly leading to increased expression of EGR1 and inducing hypomethylation in the promoter region [64]. This evidence concerns the gene EGR1 and renal fibrosis.