ZBTB4 and lung cancer: In addition, METTL3-mediated modification of m6ZBTB4 mRNA is also involved in smoking-induced EMT in lung cancer [55], Recent findings demonstrate a role for ZBTB4 in epigenetic regulation, particularly in DNA methylation, and its dysfunction has been implicated in recurrent spontaneous abortion and smoking-induced epithelial-to-mesenchymal transition in lung cancer.