Conversely, simultaneous activation of Src homologous tyrosine phosphatase (SHP2) and suppression of cytokine signaling (SOCSs) by the tumour cells [44], in addition to the IFN-γ downstream molecular activator of transcription (STAT) impede the IFN-γ immune surveillance process, subsequently preventing the tumour cells from being detected. This evidence concerns the gene PTPN11 and neoplasm.