Du et al. unveiled ginsenoside Rg3 could disrupt the proportions of MMP-9 and matrix metalloproteinase-inhibitor-1 (TIMP-1) in the HT-29 cell line’s extracellular matrix, obstructing tumour cell infiltration and metastasis, resist TGF-β then obstruct the increase of VEGF and MMPs expression, hinder tumour angiogenesis and obstruct the tumour inflammatory microenvironment [103]. Here, TIMP1 is linked to neoplasm.