PIK3CD and immunodeficiency 36 with lymphoproliferation: Autosomal dominant gain-of-function (GOF) mutation in the PIK3CD gene encoding the PI3Kδ catalytic subunit p110δ cause APDS1, whereas autosomal dominant loss-of-function (LOF) mutation in the PIK3R1 gene encoding the regulatory subunit p85α cause APDS2 [2].