To further determine whether the interactions of LINC00955 with Sp1 and TRIM25 proteins inhibit the proliferation of CRC cells, plasmids overexpressing LINC00955 lacking nucleotides 984–1135 and/or 2073–2204 were synthesized and used to construct stable transfected cell lines (Figure S2A, B). Here, SP1 is linked to colorectal carcinoma.