WDR5 and neuroblastoma: Consistent with the former studies, we proved that AC142119.1 transcript could not only bind with WDR5 protein, but also directly interact with the promoter region of MYCN. More importantly, ChIP assays revealed that the H3K4me3 levels of MYCN promoter was significantly increased or decreased after overexpression or knockdown of AC142119.1 in NB cells, meanwhile, the mRNA and protein levels of MYCN are correspondingly enhanced or inhibited.