Peripheral blood and paired tumor tissue from 63 CRC patients and peripheral blood from 33 healthy donors were evaluated by phosphoflow cytometry analysis for IL-6, IL-10, and IL-2-induced phosphorylation of p-STAT1, p-STAT3, and p-STAT5, respectively, in helper T, Treg, and cytotoxic T cell subsets. This evidence concerns the gene STAT3 and neoplasm.