The expression levels of the main genes in the Wnt signaling pathway, such as Ccnd3, Gsk3a, Ddit3, Wnt3, Wnt4, and Lrp6, were significantly increased in Krt5 expressing AEC2s compared with Krt5− AEC2s isolated from ALI mouse lungs at 3 dpi. Here, WNT3 is linked to acute respiratory distress syndrome.