Taken together, these results show that Krt5 promotes the phosphorylation of the Wnt signaling coreceptor LRP6 by binding with it and then activates the Wnt signaling pathway of Krt5 expressing AEC2s, which is the mechanism by which Krt5 expressing AEC2s participate in the repair and regeneration of alveoli after ALI. This evidence concerns the gene LRP6 and acute respiratory distress syndrome.