The expression levels of the main genes in the Wnt signaling pathway, such as Ccnd3, Gsk3a, Ddit3, Wnt3, Wnt4, and Lrp6, were significantly increased in Krt5 expressing AEC2s compared with Krt5− AEC2s isolated from ALI mouse lungs at 3 dpi. This evidence concerns the gene KRT5 and acute respiratory distress syndrome.