Although there was no significant change in muscle weight was found (Supplementary Fig. S12c), the expression of E3 ligases Trim63 and Fbxo32 was increased in the muscle of mice bearing IDH1 mutant glioma tumors, whereas it was attenuated after ivosidenib treatment (Supplementary Fig. S12d). The gene discussed is FBXO32; the disease is central nervous system cancer.