To verify that ivosetinib has a direct effect on cachexia directly, we compared the lean body weight with a similar tumor weight of 1.56 g (tumor volume 3000mm3) and found that there was a significant preservation of lean body weight in ivosidenib treated mice bearing CT26 tumor with IDH1-mutation when compared to NTC treated mice bearing CT26 tumor with IDH1-mutation (Fig. 7d). Here, IDH1 is linked to neoplasm.