Interestingly one gene, TRPC1, has interesting evidence of association (P = 6.34E−3) with POAG in the UK Biobank (defined as ICD-10 code H40, N = 11,588 cases and 383,253 controls) using SKAT-O and only missense alleles (Supplemental Table 2). The gene discussed is TRPC1; the disease is open-angle glaucoma.