In addition, the oral administration of viable L. plantarum CLP-0611 was reported to increase M2 macrophages expressing IL-10, arginase I, and CD206, which was likely involved in the amelioration of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced mice colitis, although the kinetics of macrophages was not examined in detail31. This evidence concerns the gene IL10 and colitis.