Expanded analysis of core components of the autophagosome elongation machinery (illustrated in Supplementary Fig. 2a) showed ATG16L1 to be preferentially enriched in the tumor epithelium when compared to ATG3, ATG4B, ATG5, ATG7, ATG10 and ATG12. ATG4A, ATG4C, and ATG4D were not detected, likely due to poor transcript coverage or low expression (Supplementary Fig. 2b). This evidence concerns the gene ATG4D and neoplasm.