Analysis of core members of the autophagosome elongation machinery (ATG3, ATG4A-D, ATG5, ATG7, ATG10, ATG12, ATG16L1) revealed a specific association of decreased ATG16L1 gene expression with improved immunotherapy-dependent outcome of non-MSI CRC harboring KRAS mutations. Here, ATG16L1 is linked to colorectal carcinoma.