ATG16L1 and colorectal carcinoma: Although Atg16l1 deletion sensitized CRC organoids to cytotoxicity induced by Type I IFN, TLR3, and TLR4, the cell death triggered by a combination of TNF and IFNγ in Atg16l1 KO CRC organoids was more pronounced compared to other combinations (Supplementary Fig. 10c).