ATG16L1 and neoplasm: Gene set enrichment analysis (GSEA, Hallmark genesets) revealed that in addition to the dramatically increased IFN responsive cluster, the StemHI and GP cell clusters also exhibited higher levels of IFN response genes in the Atg16l1 KO group, consistent with the generation of an inflammatory tumor microenvironment, increased tumor-intrinsic sensitivity to IFN, or some combination of the two (Fig. 3f).