Antiphospholipid syndrome (APS) is an autoimmune disease characterized by thrombosis (vascular APS) and/or pregnancy morbidity (obstetric APS) and persistent positivity of moderate to high titers of antiphospholipid antibodies (aPL) such as anti-cardiolipin (aCL), anti-ß2 glycoprotein 1 (aß2GP1) or the lupus anticoagulant (LA) in a 12-week interval. The gene discussed is ACLY; the disease is autoimmune polyendocrinopathy.