A considerable proportion of cognitively normal older adults (11%−36%) have also been found to have TDP-43 proteinopathy, with increasing prevalence with older age.21,72,73 While LATE-NC is a unique disease entity for clinical and research purposes,74 clinical identification of LATE-NC is challenging in the absence of TDP-43 biomarkers. The gene discussed is TARDBP; the disease is nevus comedonicus syndrome.