TARDBP and frontotemporal dementia: The most significant limitation in clinical practice is the absence of valid TDP-43-specific fluid or imaging biomarkers, except for genetic screening to determine if FTD is caused by GRN, C9orj72, or MAPT gene mutations.10,107,108 Therefore, diagnosis largely depends on the clinical assessment and a probabilistic method to identify likely TDP-43-related diseases.6