TARDBP and proteostasis deficiencies: While an exploration of the prognostic significance of NPS in TDP-43-related disease is still needed, NPS are associated with faster disease progression and earlier death in patients with AD.144,146 Greater awareness of FTD and other TDP-43 proteinopathies is needed to further refine diagnostic recognition, prevent the use of ineffective treatments with potential negative side effects, and identify carriers of disease-causing mutations who may be eligible for clinical trials of investigational drugs or other appropriate treatment modalities.