An Oxford study identified brain imaging discriminators via discriminant analysis of principal components combining the magnetic resonance imaging (MRI) features of MOGAD and AQP4-IgG+ NMOSD to differentiate from MS.40 The use of such a discriminatory model may be helpful in subclassifying patients with DN NMOSD/MS overlapping syndromes33,39 who in clinical practice are one of the main diagnostic challenges. The gene discussed is AQP4; the disease is myeloid sarcoma.