The PMR of CDO1 promoter in BC patients (7.46% ± 15.38) was significantly higher than that in the normal people (.19% ± .83, p < .0001) and patients with breast benign diseases (.04% ± .15, p < .0001) (Figure 8A, Supporting Information Figure S2H). The gene discussed is CDO1; the disease is breast fibrocystic disease.