Huan et al. indicated that hypoxia-induced lncRNA LUCAT1 bound to PTBP1 and altered the splicing of transcript subsets, including CD44, APP, CLSTN1 and ZNF207, which have been implicated in important cellular processes such as growth, DNA damage response, apoptosis, and drug resistance in cancer cells [47]. This evidence concerns the gene CLSTN1 and cancer.