In addition, IHC staining results demonstrated that compared to the control group, the expression of LDHA, HK2, PKM2, PTBP1, Ki-67, N-cadherin, and Vimentin was obviously decreased, while the level of PKM1 and E-cadherin was markedly increased in tumor tissues of the sh-CCAT1 group (Fig. 4D). The gene discussed is HK2; the disease is neoplasm.