In summary, our study has demonstrated for the first time that CCAT1, a glycolysis-related lncRNA, functions by impeding ubiquitin-mediated degradation of PTBP1 and preserving its stability, leads to an elevation of PKM2/PKM1 ratio and glycolysis levels, and ultimately promotes the progression of GC (Fig. 9). This evidence concerns the gene PTBP1 and gastric cancer.