Following previous evidence on the role of DOT1L in HOXA gene expression in KMT2A::AFF1+ ALL cells, [9, 24] we examined the HOXA locus and found that HOXA9 and HOXA10 were expression at comparable levels in both SEM and SEMPINO_RES (Fig. 4A). Here, HOXA10 is linked to acute lymphoblastic leukemia.