DOT1L and acute lymphoblastic leukemia: In contrast, we here specifically focused on the behavior and epigenetic regulation of DOT1L-associated KMT2A fusion-driven target genes and on how the transcriptomic landscape changes in KMT2A-rearranged ALL cells that are able to evade leukemic cell death during prolonged inhibition of DOT1L-mediated H3K79 methylation.