AFF1 and acute lymphoblastic leukemia: Likewise, ~ 25% of the genes we previously reported to be differentially expressed in response to siRNA-mediated repression of KMT2A::AFF1 and KMT2A:MLLT1 in KMT2A-rearranged ALL cells, [20] as well as a fourth of the genes reported to display binding of KMT2A:AFF1 that spreads beyond the gene promoter and well into the gene body as recently identified in SEM cells by Kerry et al., [25] were downregulated in SEMPINO_RES (Fig. 2D, Table S1).