AFF1 and acute leukemia: Approximately half of the KMT2A::AFF1 target genes identified by Guenther et al. [24] were downregulated in SEMPINO_RES (Fig. 2D, Table S1), as well as a quarter of the top 50 genes associated with H3K79 methylation in KMT2A-rearranged acute leukemia patient samples as identified by Krivtsov et al. [9].