However, we also identified a link between a novel RyR2 mutation (RyR2-H29D) and short-coupled PMVT among family members who experienced syncope and a short-coupled PMVT at rest and not with exercise, consistent with a clinical phenotype that was distinct from CPVT [6]. Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.