VEGFC and bacterial infectious disease: The application of PI3K inhibitor does not affect IL-10-depnedent AMPKα1 activation, and AMPKα1 seems to function in parallel to PI3K pathway to orchestrate the anti-inflammatory phenotype by phosphorylating STAT3 [91], However, a recent study in bacterial infection model demonstrated that AMPK activated by vascular endothelial growth factor C (VEGFC) signaling promotes glycolysis and inflammasome activation in macrophages to facilitate the clearance of bacteria [93].