However, considering Menin as a tumor suppressor, the elevated Menin might also mediate hepatic MAFLD towards carcinogenesis progression, such as NASH (nonalcoholic steatohepatitis) and HCC (hepatocellular carcinoma), due to Menin's function in mediating inflammation (Additional file 2: Figure S3; [9, 20]. This evidence concerns the gene MEN1 and neoplasm.