INS and Hepatic steatosis: Liver specific ablation of Men1 gene expression in healthy mice induces hepatic steatosis under high-fat dietary conditions [11], with significantly increased liver triglycerides coupled with increased liver steatosis and inflammatory markers, as well as increased serum insulin, glucose level and type 2 diabetic phenotype [53], suggesting hepatic menin is required for regulation of diet-induced glucose and lipid metabolism.