However, considering Menin as a tumor suppressor, the elevated Menin might also mediate hepatic MAFLD towards carcinogenesis progression, such as NASH (nonalcoholic steatohepatitis) and HCC (hepatocellular carcinoma), due to Menin's function in mediating inflammation (Additional file 2: Figure S3; [9, 20]. Here, MEN1 is linked to hepatocellular carcinoma.