LEF1 and neoplasm: Western blot analysis showed that the protein levels of Wnt/β-Catenin downstream gene-encoded products were reduced in UCHL3-deficient tumor tissues, including LEF1, Axin2, C-myc and Cyclin D1, confirming that the abolition of UCHL3 inhibited WNT signaling pathway activation, which is consistent with our aforementioned experiments.