Compared with the HG + HF + Exos group, the expression of PI3K, p-AKT, Ras, p-Erk1/2, BCL-2, SNAP-25, and VGluT-1 increased significantly, and the expression of Cleaved Caspase-3 and Bax decreased significantly in the HG + HF + AE + Exos group. The gene discussed is MAPK3; the disease is hydrops fetalis.