Our previous study has reported that exercise is able to downregulate MALAT1 to reduce resistin and can increase microRNA-382-3p (miR-382-3p) expression in the serum of insulin resistance mice (Liu et al. 2019) AE is associated with increased brain-derived neurotrophic factor (BDNF) in the hippocampus of diabetic rats (Gaitan et al. 2021). Here, RETN is linked to Insulin resistance.