In addition, compared with the HG + HF + AE + Exos + DMSO group, the expression of PI3K, p-AKT, Ras, p-Erk1/2, BCL-2, SNAP-25, and VGluT-1 decreased significantly, and the expression of Cleaved Caspase-3 and Bax increased significantly in the HG + HF + AE + Exos + GW4869 group (Fig. 5F–H). This evidence concerns the gene AKT1 and hydrops fetalis.