In animal experiments, RT-qPCR results showed that compared with the HF + Exos + sh-NC group, the MALAT1 expression in the HF + Exos + sh-MALAT1 group was significantly reduced; no significant difference was found between the HF + Exos and HF + Exos + sh-NC groups (Fig. 8A). This evidence concerns the gene MALAT1 and hydrops fetalis.