Western blot results showed that compared with the HF + Exos + agomir-NC group, expressions of INSR, IRS-1, and IRS-2, as well as PI3K, p-AKT, Ras, and p-Erk1/2 in the mouse hippocampus significantly decreased in the HF + Exos + miR-382-3p agomir group (Fig. 10H, I). Here, IRS1 is linked to hydrops fetalis.