Compared with the control group, HER2 CAR-M significantly inhibited the proliferation of HER2hi SKOV3 cells (Fig. 5B–D and Additional file 1: Fig. S4A, D, E), suggesting that HER2 CAR-M could efficiently repress the growth of HER2hi ovarian cancer cells-formed tumor. Here, ERBB2 is linked to ovarian cancer.