The collagen and calcium binding EGF domains 1 gene (CCBE1), a proposed tumor suppressor, was increased in skin KS samples from those with KS alone whereas the gene expression was lower among those with KS with concurrent KAD (log2FC 0.39 vs. -1.29 p = 0.008, Fig. 3C). This evidence concerns the gene CCBE1 and neoplasm.