To investigate the potential impact of PDE4D7 knockdown on DNA repair mechanisms, we used the REACTOME homology-directed repair (HDR) of the DNA double-strand breaks gene set (reactome.org: R-HSA-5693538) and expanded it with additional genes from other DDR pathways previously reported to be altered in PCa (Supplementary Table 5) [36]. Here, ALB is linked to posterior cortical atrophy.