AR and neoplasm: To explore the potential clinical relevance of these findings, we also analysed the expression of hallmark AR response genes and key markers for NED in RNAseq data of 533 human patient samples described previously [32] and found that all tested AR response genes were downregulated alongside reduced PDE4D7 expression in these patient tumours, while the expression of AR itself did not change (Supplementary Fig. 6A).