We then reanalysed RNAseq data from 533 clinical samples [32] focusing on the expression of PCa-relevant DDR genes, revealing the most significant increase in BRCA2 expression with decreasing PDE4D7 expression (P < 0.0001), along with a range of other DDR-related genes (Fig. 2l and Supplementary Fig. 8). The gene discussed is BRCA2; the disease is posterior cortical atrophy.