Also, histologic tumour grade and ER status were an independent predictor of pCR (OR, 3.12; 95% CI, 1.60–6.00; P = 0.001), (OR, 0.35; 95%CI, 0.18–0.67; P = 0.001, for grade 3 and ER+ tumours, respectively) (Fig. 2). The gene discussed is ESR1; the disease is neoplasm.