Decreased expression of pro-inflammatory genes, which are associated with neurodegenerative disease or astrocyte and microglia phenotypes Cd40, C1qB, Cd68, Cd45, Aqp-4, Il1α, Fkbp5, Ggta1, Cd16, H2-T23, and Serping1, was observed following C-32:6 treatment and C1qC, Tspo, and Gbp2 with FFA C-34:6. Here, GBP2 is linked to neurodegenerative disease.