In the context of stroke, Gpc4, a member of the glypican family, has been shown to exert neuroprotective effects promoting neuronal survival, angiogenesis, neurogenesis, and regulation of synaptic plasticity through regulation of various growth factors such as fibroblast growth factors (FGFs), Wnts, and bone morphogenic proteins (BMPs)34. This evidence concerns the gene CLN5 and Stroke.