HMOX1 and acute kidney injury: Silencing pannexin 1 (PANX1), an ATP release channel, reduced the expression of proinflammatory molecules, upregulated HO-1 expression, attenuated the MAPK/ERK pathway to alleviate NCOA4-mediated ferritinophagy, and ultimately inhibited ferroptosis and alleviated IRI-AKI (Fig. 2) [148].