GPX4 and kidney disorder: Although iron metabolism abnormalities and lipid peroxidation mediated by ferroptosis are important mechanisms that regulate kidney diseases and ferroptosis-related defense mechanisms, including the system Xc-/GSH/GPX4 pathway, the mitochondrial pathway and the FSP1/CoQ10/NAD(P)H pathway, the specific details and crosstalk among these pathways are still not well understood.