ACSL4 and renal cell carcinoma: The expression of key regulators of ferroptosis, such as GPX4, SLC7A11, and FSP1, was significantly upregulated, but ACSL4 expression was obviously downregulated in three major types of RCC based on The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases (Fig. 3A).