As manifested by the IVIS assay and micro-CT scans, more extensive lung metastasis and larger tumor mass were observed in mice treated with the scrRNA circuit and apatinib, while lung metastasis was dramatically limited and tumor size were significantly reduced by the treatment with the anti-VEGFR2 circuit (Figs. 6C, D and S6B, C). Here, KDR is linked to neoplasm.