We further investigated the usage of two B7-H3 isoforms and found that, while acute myeloid leukemia (AML) lacked B7-H3 expression, 4Ig was the predominant form expressed in all tumor types analyzed except for ovarian (OV) cancer where 2Ig and 4Ig shared similar expression (Fig. 1d). The gene discussed is CD276; the disease is acute myeloid leukemia.