Moreover, the cell surface B7-H3 protein was highly expressed in multiple human tumor cell lines, belong to pancreatic adenocarcinoma (PADC), neuroblastoma (NB), ovarian serous cystadenocarcinoma (OV), lung adenocarcinoma (LUAD), epidermoid carcinoma, and hepatocellular carcinoma (HCC) (Fig. 1b). This evidence concerns the gene CD276 and pancreatic adenocarcinoma.