In comparison to CD19 CAR-T cells, B12(VHH)-CAR-T cells significantly inhibited tumor growth, followed by C4(VHH)-CAR-T cells, whereas G8(VHH)-CAR-T cells and 376.96(scFv)-CAR-T cells were ineffective (Fig. 6c, d). The gene discussed is CD19; the disease is neoplasm.