CD4 and skin disorder: Due to Th17 cells is a variety of widely-acknowledged pathogenic factor in psoriasis [26, 27], we examined both ratio of CD4+ T cells in dermis and percentage of Th17 cells in dermis, and interestingly, we delineated that EHMT2 knock out mouse accompanied with deficient capacity on Th17 cells polarization and reduced infiltrated CD4+ T cells (Fig. 3G, H), which brought constrained inflammation during psoriasis-like dermatitis.