In order to uncover the explicit function of EHMT2 on psoriasis, we generated keratinocyte specific knock-out of Ehmt2 mouse by means of crossing mice with loxP-flanked Ehmt2 alleles (Ehmt2fl/fl) with Keratin14-Cre (K14) mice to delete Ehmt2 in keratinocytes, and testified its efficiency (Fig. 2C, Fig. S2A, B). The gene discussed is EHMT2; the disease is psoriasis.