Apart from showing that different proteasomal proteins are elevated in the blood of COVID-19 patients, we could further differentiate that both the constitutional- and the immune-proteasome β subunits were elevated; specifically, the constitutional β1 (PSMB6) and β5 (PSMB5) subunits, and the immunoproteasome subunits β2i (PSMB10) and β5i (PSMB8). This evidence concerns the gene PSMB5 and COVID-19.