SOCS3 and neoplasm: Conspicuous tumor-specific differences are also seen for four of the five cCREs with the highest signals with FDR < 0.05, including an intronic enhancer in the Suppressor of cytokine signaling 3 (Socs3) gene (Fig. 5f)47, the promoter of the Nuclear paraspeckle assembly transcript 1 (Neat1) long non-coding RNA gene (Fig. 5g)48, a proximal enhancer of the Cyclin D1 (Ccnd1) gene (Fig. 5h)49 and the C/EBPβ promoter (Fig. 5j)50.