Even more striking differences are seen for the next two most significant differences at the bidirectional promoter of the Insulin growth factor 2 (Igf2) (Fig. 5e) and the Collagen type 1 alpha 1 (Col1a1) gene promoter (Fig. 5d)45,46, where the RELA-driven tumor shows a strong signal but there is no perceptible signal in the region for normal, PDGFB-driven and YAP1-driven samples. This evidence concerns the gene IGF2 and neoplasm.