To further investigate the role of SCARB2 in HCC, we generated mice with liver-specific conditional Scarb2 knockout (Supplementary Fig. 2a) by crossing Scarb2-floxed (Scarb2F/F) mice and mice with hepatocyte-specific expression of Cre recombinase (CreAlb) (Supplementary Fig. 2b). This evidence concerns the gene SCARB2 and hepatocellular carcinoma.