Our data suggest that SCARB2 expression was enhanced in human HCC samples compared with normal liver tissues, and SCARB2 expression is positively correlated with known CSC markers (CD133, EpCAM or CD24) in HCC patients, which was consistent with the findings that another scavenger receptor CD36 was also reported to mainly enriched in CSCs and positively correlated with previously reported CSC markers CD133 and integrin alpha 6 expression in Glioblastoma41. This evidence concerns the gene PROM1 and hepatocellular carcinoma.