SIRT1 and hepatocellular carcinoma: However, the decrease in MYC acetylation mediated by the deacetylase HDAC3 but not SIRT1 was restored by overexpression of SCARB2 in HCC cells (Fig. 4d and Supplementary Fig. 4e), indicating that SCARB2 affects MYC acetylation mainly in an HDAC3-dependent manner.