PLGM can suspend insulin therapy when hypoglycemia is either predicted or present, and the use of PLGM has been shown to reduce time spent in hypoglycemia compared with SAP therapy alone.34 35 Such insulin pumps could hence improve the chance of reaching the combined treatment goal of an HbA1c ≤48 mmol/mol without frequent hypoglycemic events. Here, INS is linked to Hypoglycemia.