In our analyses of TCGA data, we unexpectedly noticed that expression of the TRIM69 mRNA in basal breast cancers was very strongly associated with gene signatures for centrosome amplification (CA20, Figure 1A, B), aneuploidy (Figure 1C), and Homologous Recombination Deficiency (HRD, Figure 1D). The gene discussed is TRIM69; the disease is breast cancer.