Recently, Lippincott-Schwartz and Ward groups identified annexin A11 (Anxa11), a vesicular trafficking protein linked to ALS (68), as the tethering adaptor for G3BP stress granule assembly factor 1 (G3bp1) granule association with motile lysosomal-associated membrane protein 1 (Lamp1)-positive vesicles (62). Here, G3BP1 is linked to amyotrophic lateral sclerosis.