Notably, we found that autophagy-related proteins, such as ULK1 and LC3II/LC3I ratio, were reduced in NASH patients (Figure 1B,C) and NASH mouse models (Figure 3A–C), whereas the expression of AMPK in NASH groups was similar to that in control groups (Figure 1B and Fig. S4A). The gene discussed is PRKAA1; the disease is metabolic dysfunction-associated steatohepatitis.