In addition, we found a number of factors that have been described as regulators of CSC self-renewal factors.47 These include HOXA4, HOXA5, HOX3A, YAP1, MSI2, HIF1A, NOTCH2, MEIS1, OCT4, and NES, which are known as self-renewal factors in CSCs in various cancers, and enriched by gemcitabine treatment but decreased by I-BRD9 treatment, particularly on the combined treatment with gemcitabine and I-BRD9 (Supplementary Figure 7A). This evidence concerns the gene HOXA4 and cancer.