POU5F1 and familial pancreatic carcinoma: The FG pancreatic cancer cells used for this screening were genetically engineered, with the sequence coding for enhanced green fluorescent protein (eGFP) integrated in the endogenous locus via TALEN-mediated recombination, resulting in controlled expression of a OCT4-eGFP fusion protein driven by the endogenous OCT4 promoter (Supplementary Figure 1A).