Moreover, distinct C-terminal fragments of TDP-43 with the specific structure for ALS or FTLD-TDP patients have been detected in multiple brain regions and the spinal cords of ALS and FTLD-TDP patients (5, 9, 59, 60), suggesting that TDP-43 with the same pathological structure is propagated to different brain regions in a prion-like manner. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.