In addition to MCF-7 cells, we found that H520 (LUSC), PC-9 (LUAD) and T47D (luminal A BRCA) cancer cell lines, which display varying levels of SOX2 expression (Supplementary Figure S1E), also gained substantial enhancer features at SRR124 and SRR134 when compared with normal tissue (Figure 1E) (85,106,108,127). Here, SOX2 is linked to cancer.