SOX2 and neoplasm: We found that both MCF-7 (P = 3.53 × 10−4, t-test) and PC-9 (P = 1.26 × 10−5) ΔENH–/– cells showed a significant decrease (> 50%) in their ability to form colonies compared with ΔENH+/+ cells (Figure 2D), further underscoring the crucial role of SRR124–134-driven SOX2 overexpression in sustaining the elevated tumor initiation potential in both BRCA and LUAD.