GBM and LGG tumors lacked accessible chromatin at this cluster but displayed increased chromatin accessibility at the SRR1 and SRR2 enhancers (Supplementary Figure S4A; Supplementary Table S26), which is consistent with the evidence that SRR1 and SRR2 drive SOX2 expression in the neural lineage (23,71,135). The gene discussed is SOX2; the disease is glioblastoma.