MECOM and cancer: Overall, there were 33 cancer-related genes (Data Supplement, Table S7), including ABI3BP, CHCHD6, EPHA6, KALRN, KBTBD12, MCM2, MGLL, PPP2R3A, PROS1, FGF12, MECOM, SERPINI1, MED12L, and ZBTB20 (Fig 4B; Data Supplement, Table S8), lost in all nine cases of RMS and lost in at least two of the three tested cell lines.