The electrical stimulation significantly decreased TNF concentrations in circulating blood and resulted in significant improvement of clinical signs and symptoms according to the standard disease activity and patient disability indices [DAS28-CRP and HAQ-DI, respectively].38,39 In inflammatory bowel disease [IBD], Sinniger et al. reported a 12-month study in nine biologic-naive CD patients with moderately active disease at entry. This evidence concerns the gene TNF and inflammatory bowel disease.