HSV-1 uses several routes of entry to initiate infection of cells including HVEM (TNFRSF14), nectin-1, nectin-2, 3-O-sulfated heparan sulfate (3-OS-HS), paired immunoglobulin-like type 2 receptor (PILRα), non-muscle myosin heavy chain IIA (NMHC-IIA), and myelin-associated glycoprotein (MAG) [68–72]. This evidence concerns the gene NECTIN2 and infection.