The influence of the patients’ disease spectrum on the obtained HEV seroprevalence has also to be discussed with regard to a large Chinese study reporting positive anti-HEV-IgM in only 0.54% of patients and 0.68% of controls, but in one of three GBS and two of 26 patients with viral encephalitis [20]. Here, CD40LG is linked to Guillain-Barre syndrome.